Genome-wide association study of kidney function decline in individuals of European descent
Identifieur interne : 003907 ( Main/Exploration ); précédent : 003906; suivant : 003908Genome-wide association study of kidney function decline in individuals of European descent
Auteurs : Mathias Gorski [Allemagne] ; Adrienne Tin [États-Unis] ; Maija Garnaas [États-Unis] ; Gearoid M. Mcmahon [États-Unis] ; Audrey Y. Chu ; Bamidele O. Tayo [États-Unis] ; Cristian Pattaro ; Alexander Teumer [Allemagne] ; Daniel I. Chasman [États-Unis] ; John Chalmers [Australie] ; Pavel Hamet [Canada] ; Johanne Tremblay ; Marc Woodward [Australie] ; Thor Aspelund [Islande] ; Gudny Eiriksdottir [Islande] ; Vilmundur Gudnason [Islande] ; Tammara B. Harris [États-Unis] ; Lenore J. Launer [États-Unis] ; Albert V. Smith [Islande] ; Braxton D. Mitchell ; Jeffrey R. O'Connell ; Alan R. Shuldiner ; Josef Coresh [États-Unis] ; Man Li [États-Unis] ; Paul Freudenberger [Autriche] ; Edith Hofer [Autriche] ; Helena Schmidt [Autriche] ; Reinhold Schmidt [Autriche] ; Elizabeth G. Holliday [Australie] ; Paul Mitchell [Australie] ; Jie Jin Wang [Australie] ; Ian H. De Boer [États-Unis] ; Guo Li [États-Unis] ; David S. Siscovick [États-Unis] ; Zoltan Kutalik [Suisse] ; Tanguy Corre [Suisse] ; Peter Vollenweider ; Gérard Waeber ; Jayanta Gupta ; Peter A. Kanetsky ; Shih-Jen Hwang [États-Unis] ; Matthias Olden [Allemagne, États-Unis] ; Qiong Yang [États-Unis] ; Mariza De Andrade [États-Unis] ; Elizabeth J. Atkinson [États-Unis] ; Sharon L. R. Kardia [États-Unis] ; Stephen T. Turner [États-Unis] ; Jeanette M. Stafford [États-Unis] ; Jingzhong Ding [États-Unis] ; Yongmei Liu [États-Unis] ; Cristina Barlassina [Italie] ; Daniele Cusi [Italie] ; Erika Salvi [Italie] ; Jan A. Staessen [Pays-Bas, Belgique] ; Paul M. Ridker [États-Unis] ; Harald Grallert [Allemagne] ; Christa Meisinger [Allemagne] ; Martina Müller-Nurasyid [Allemagne] ; Bernhard K. Kr Mer [Allemagne] ; Holly Kramer [États-Unis] ; Sylvia E. Rosas [États-Unis] ; Ilja M. Nolte [Pays-Bas] ; Brenda W. Penninx [Pays-Bas] ; Harold Snieder [Pays-Bas] ; Fabiola Del Greco [Italie] ; Andre Franke [Allemagne] ; Ute Nöthlings [Allemagne] ; Wolfgang Lieb [Allemagne] ; Stephan J. L. Bakker [Pays-Bas] ; Ron T. Gansevoort [Pays-Bas] ; Pim Van Der Harst [Pays-Bas] ; Abbas Dehghan [Pays-Bas] ; Oscar H. Franco [Pays-Bas] ; Albert Hofman [Pays-Bas] ; Fernando Rivadeneira [Pays-Bas] ; Sanaz Sedaghat [Pays-Bas] ; André G. Uitterlinden [Pays-Bas] ; Stefan Coassin [Autriche] ; Margot Haun [Autriche] ; Barbara Kollerits [Autriche] ; Florian Kronenberg [Autriche] ; Bernhard Paulweber ; Nicole Aumann [Allemagne] ; Karlhans Endlich [Allemagne] ; Mike Pietzner [Allemagne] ; Uwe Völker [Allemagne] ; Rainer Rettig [Allemagne] ; Vincent Chouraki [France] ; Catherine Helmer [France] ; Jean-Charles Lambert ; Marie Metzger [France] ; Benedicte Stengel [France] ; Terho Lehtim Ki [Finlande] ; Leo-Pekka Lyytik Inen [Finlande] ; Olli Raitakari [Finlande] ; Andrew Johnson [États-Unis] ; Afshin Parsa ; Murielle Bochud [Suisse] ; Iris M. Heid [Allemagne] ; Wolfram Goessling [États-Unis] ; Anna Köttgen [États-Unis, Allemagne] ; H. Linda Kao [États-Unis] ; Caroline S. Fox [États-Unis] ; Carsten A. Böger [Allemagne]Source :
- Kidney international [ 0085-2538 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Cadherins, N-Acetylgalactosaminyltransferases, Uromodulin.
- genetics : European Continental Ancestry Group, Glomerular Filtration Rate, Renal Insufficiency.
- Animals, Genome, Human, Genome-Wide Association Study, Humans.
Abstract
Genome wide association studies (GWAS) have identified multiple loci associated with cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time is missing. Here we conducted a GWAS meta-analysis among 63,558 participants of European descent, initially from 16 cohorts with serial kidney function measurements within the CKDGen Consortium, followed by independent replication among additional participants from 13 cohorts. In stage 1 GWAS meta-analysis, SNPs at
Url:
DOI: 10.1038/ki.2014.361
PubMed: 25493955
PubMed Central: 4425568
Affiliations:
- Allemagne, Australie, Autriche, Belgique, Canada, Finlande, France, Islande, Italie, Pays-Bas, Suisse, États-Unis
- Bade-Wurtemberg, Bavière, Canton de Vaud, Caroline du Nord, District de Fribourg-en-Brisgau, District de Haute-Bavière, District de Karlsruhe, Finlande occidentale, Groningue (province), Hollande-Méridionale, Illinois, Maryland, Massachusetts, Michigan, Minnesota, Nouvelle-Galles du Sud, Schleswig-Holstein, Washington (État)
- Cambridge (Massachusetts), Fribourg-en-Brisgau, Groningue (ville), Kiel, Lausanne, Mannheim, Munich, Rotterdam, Seattle, Sydney, Turku
- Université Harvard, Université de Groningue, Université de Sydney, Université de Washington
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Le document en format XML
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Harris</name><affiliation wicri:level="2"><nlm:aff id="A16">Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C-309, Bethesda MD 20892 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C-309</wicri:cityArea></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation wicri:level="2"><nlm:aff id="A16">Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C-309, Bethesda MD 20892 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C-309</wicri:cityArea></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="A14">Icelandic Heart Association, Research Institute, Holtasmari 1, 201 Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Research Institute, Holtasmari 1, 201 Kopavogur</wicri:regionArea><wicri:noRegion>201 Kopavogur</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">University of Iceland, Sæmundargötu 2, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Sæmundargötu 2, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:aff id="A17">Department of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, University of Maryland School of Medicine, 660 W Redwood St, RM 492, Baltimore, MD, 21212</nlm:aff><wicri:noCountry code="subfield">21212</wicri:noCountry></affiliation><affiliation><nlm:aff id="A18">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, University of Maryland School of Medicine, 660 W Redwood St, RM 492, Baltimore, MD, 21212</nlm:aff><wicri:noCountry code="subfield">21212</wicri:noCountry></affiliation></author><author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name><affiliation><nlm:aff id="A17">Department of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, University of Maryland School of Medicine, 660 W Redwood St, RM 492, Baltimore, MD, 21212</nlm:aff><wicri:noCountry code="subfield">21212</wicri:noCountry></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A17">Department of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, University of Maryland School of Medicine, 660 W Redwood St, RM 492, Baltimore, MD, 21212</nlm:aff><wicri:noCountry code="subfield">21212</wicri:noCountry></affiliation><affiliation><nlm:aff id="A18">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, University of Maryland School of Medicine, 660 W Redwood St, RM 492, Baltimore, MD, 21212</nlm:aff><wicri:noCountry code="subfield">21212</wicri:noCountry></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation wicri:level="2"><nlm:aff id="A3">Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A19">Welch Center for Prevention, Epidmiology and Clinical Research, 2024 E Monument St, Suite 2-600, Baltimore, MD 21287</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Welch Center for Prevention, Epidmiology and Clinical Research, 2024 E Monument St, Suite 2-600, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name><affiliation wicri:level="2"><nlm:aff id="A3">Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Freudenberger, Paul" sort="Freudenberger, Paul" uniqKey="Freudenberger P" first="Paul" last="Freudenberger">Paul Freudenberger</name><affiliation wicri:level="1"><nlm:aff id="A20">Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria, Harrachgasse 21, 8010 Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria, Harrachgasse 21, 8010 Graz</wicri:regionArea><wicri:noRegion>8010 Graz</wicri:noRegion></affiliation></author><author><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology and Institute for Medical Informatics, Statistics and Documentation Medical University Graz, Austria, Auenbruggerplatz 22 and Auenbruggerplatz2, 8036 Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology and Institute for Medical Informatics, Statistics and Documentation Medical University Graz, Austria, Auenbruggerplatz 22 and Auenbruggerplatz2, 8036 Graz</wicri:regionArea><wicri:noRegion>8036 Graz</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A20">Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria, Harrachgasse 21, 8010 Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria, Harrachgasse 21, 8010 Graz</wicri:regionArea><wicri:noRegion>8010 Graz</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A22">Department of Neurology, Medical University Graz, Austria, Auenbruggerplatz 22, 8036 Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Graz, Austria, Auenbruggerplatz 22, 8036 Graz</wicri:regionArea><wicri:noRegion>8036 Graz</wicri:noRegion></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><nlm:aff id="A23">University of Newcastle, Centre for Clinical Epidemiology & Biostatistics, CReDITSS, HMRI, C/-University Drive, Callaghan NSW 2308, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Centre for Clinical Epidemiology & Biostatistics, CReDITSS, HMRI, C/-University Drive, Callaghan NSW 2308</wicri:regionArea><wicri:noRegion>Callaghan NSW 2308</wicri:noRegion></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation wicri:level="4"><nlm:aff id="A24">University of Sydney, Westmead Millennium Institute, Centre for Vision Research, Westmead Millennium Institute, University of Sydney C24, Westmead Hospital, NSW 2145 Australia</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation wicri:level="4"><nlm:aff id="A24">University of Sydney, Westmead Millennium Institute, Centre for Vision Research, Westmead Millennium Institute, University of Sydney C24, Westmead Hospital, NSW 2145 Australia</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="De Boer, Ian H" sort="De Boer, Ian H" uniqKey="De Boer I" first="Ian H." last="De Boer">Ian H. De Boer</name><affiliation wicri:level="2"><nlm:aff id="A25">University of Washington, Box 359606, 325 9th Ave, Seattle, WA 98104</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>University of Washington, Box 359606, 325 9th Ave, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation wicri:level="4"><nlm:aff id="A26">Cardiovascular Health Research Unit, University of Washington, Seattle</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><affiliation wicri:level="4"><nlm:aff id="A27">Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA (USA)</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation wicri:level="3"><nlm:aff id="A28">Service of Medical Genetics, Lausanne University Hospital, DGM, rue du Bugnon 27, 1005,Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Service of Medical Genetics, Lausanne University Hospital, DGM, rue du Bugnon 27, 1005,Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A29">Swiss Institute of Bioinformatics, DGM, rue du Bugnon 27, 1005,Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Bioinformatics, DGM, rue du Bugnon 27, 1005,Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Corre, Tanguy" sort="Corre, Tanguy" uniqKey="Corre T" first="Tanguy" last="Corre">Tanguy Corre</name><affiliation wicri:level="3"><nlm:aff id="A28">Service of Medical Genetics, Lausanne University Hospital, DGM, rue du Bugnon 27, 1005,Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Service of Medical Genetics, Lausanne University Hospital, DGM, rue du Bugnon 27, 1005,Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A30">Internal Medicine Department, Lausanne University Hospital, Rue du Bugnon 46, CH-1005 Lausanne</nlm:aff><wicri:noCountry code="subfield">CH-1005 Lausanne</wicri:noCountry></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gérard" last="Waeber">Gérard Waeber</name><affiliation><nlm:aff id="A30">Internal Medicine Department, Lausanne University Hospital, Rue du Bugnon 46, CH-1005 Lausanne</nlm:aff><wicri:noCountry code="subfield">CH-1005 Lausanne</wicri:noCountry></affiliation></author><author><name sortKey="Gupta, Jayanta" sort="Gupta, Jayanta" uniqKey="Gupta J" first="Jayanta" last="Gupta">Jayanta Gupta</name><affiliation><nlm:aff id="A31">The Perelman School of Medicine at the University of Pennsylvania, Center for Clinical Epidemiology and Biostatistics</nlm:aff><wicri:noCountry code="subfield">Center for Clinical Epidemiology and Biostatistics</wicri:noCountry></affiliation></author><author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name><affiliation><nlm:aff id="A31">The Perelman School of Medicine at the University of Pennsylvania, Center for Clinical Epidemiology and Biostatistics</nlm:aff><wicri:noCountry code="subfield">Center for Clinical Epidemiology and Biostatistics</wicri:noCountry></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation wicri:level="1"><nlm:aff id="A6">NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702</wicri:regionArea><wicri:noRegion>Framingham MA 01702</wicri:noRegion></affiliation></author><author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93042 Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93042 Regensburg</wicri:regionArea><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702</wicri:regionArea><wicri:noRegion>Framingham MA 01702</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation wicri:level="1"><nlm:aff id="A6">NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702</wicri:regionArea><wicri:noRegion>Framingham MA 01702</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A32">Boston University School of Public Health, Department of Biostatistics, 715 Albany St, Boston, MA 02118</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University School of Public Health, Department of Biostatistics, 715 Albany St, Boston</wicri:cityArea></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation wicri:level="2"><nlm:aff id="A33">Mayo Clinic, 200 First Street SW, Rochester, MN 55905</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, 200 First Street SW, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name><affiliation wicri:level="2"><nlm:aff id="A33">Mayo Clinic, 200 First Street SW, Rochester, MN 55905</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, 200 First Street SW, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name><affiliation wicri:level="2"><nlm:aff id="A34">University of Michigan, 1415 Washington Heights, #4659, Ann Arbor, MI 48109-2019</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>University of Michigan, 1415 Washington Heights, #4659, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name><affiliation wicri:level="2"><nlm:aff id="A33">Mayo Clinic, 200 First Street SW, Rochester, MN 55905</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, 200 First Street SW, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Stafford, Jeanette M" sort="Stafford, Jeanette M" uniqKey="Stafford J" first="Jeanette M." last="Stafford">Jeanette M. Stafford</name><affiliation wicri:level="2"><nlm:aff id="A35">Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name><affiliation wicri:level="2"><nlm:aff id="A36">Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation wicri:level="2"><nlm:aff id="A37">Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Barlassina, Cristina" sort="Barlassina, Cristina" uniqKey="Barlassina C" first="Cristina" last="Barlassina">Cristina Barlassina</name><affiliation wicri:level="1"><nlm:aff id="A38">Department of Health Science, University of Milano, Viale Ortles 22/4, 20139, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Science, University of Milano, Viale Ortles 22/4, 20139, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name><affiliation wicri:level="1"><nlm:aff id="A38">Department of Health Science, University of Milano, Viale Ortles 22/4, 20139, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Science, University of Milano, Viale Ortles 22/4, 20139, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation><affiliation><nlm:aff id="A39">Division of Nephrology, San Paolo Hospital, Via A Di Rudiní, 8 20142 MILANO</nlm:aff><wicri:noCountry code="subfield">8 20142 MILANO</wicri:noCountry></affiliation></author><author><name sortKey="Salvi, Erika" sort="Salvi, Erika" uniqKey="Salvi E" first="Erika" last="Salvi">Erika Salvi</name><affiliation wicri:level="1"><nlm:aff id="A38">Department of Health Science, University of Milano, Viale Ortles 22/4, 20139, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Science, University of Milano, Viale Ortles 22/4, 20139, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A" last="Staessen">Jan A. Staessen</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Epidemiology, Maastricht University, Maastricht, Netherlands, PO Box 616, 6200 MD Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Maastricht University, Maastricht, Netherlands, PO Box 616, 6200 MD Maastricht</wicri:regionArea><wicri:noRegion>6200 MD Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Sciences, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block d, Level 00, B-3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Sciences, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block d, Level 00, B-3000 Leuven</wicri:regionArea><wicri:noRegion>B-3000 Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation wicri:level="2"><nlm:aff id="A7">Brigham and Women's Hospital, Division of Preventive Medicine, 900 Commonwealth Ave, 3rd Floor, Boston MA 02215</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital, Division of Preventive Medicine, 900 Commonwealth Ave, 3rd Floor</wicri:cityArea></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation wicri:level="1"><nlm:aff id="A42">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A43">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A44">German Center for Diabetes Research, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Diabetes Research, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation wicri:level="1"><nlm:aff id="A42">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation wicri:level="3"><nlm:aff id="A45">DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A46">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A47">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A48">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K." last="Kr Mer">Bernhard K. Kr Mer</name><affiliation wicri:level="3"><nlm:aff id="A49">University Medical Centre Mannheim, 5th Department of Medicine, University of Heidelberg, Theodor Kutzer Ufer 1-3, 68167, Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Centre Mannheim, 5th Department of Medicine, University of Heidelberg, Theodor Kutzer Ufer 1-3, 68167, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Kramer, Holly" sort="Kramer, Holly" uniqKey="Kramer H" first="Holly" last="Kramer">Holly Kramer</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Public Health Services, Loyola Medical Center, 2160 S First Avenue, Maywood, IL 60153, 2160 S First Avenue, Maywood, IL 60153</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Public Health Services, Loyola Medical Center, 2160 S First Avenue, Maywood, IL 60153, 2160 S First Avenue, Maywood</wicri:cityArea></affiliation></author><author><name sortKey="Rosas, Sylvia E" sort="Rosas, Sylvia E" uniqKey="Rosas S" first="Sylvia E." last="Rosas">Sylvia E. Rosas</name><affiliation wicri:level="2"><nlm:aff id="A50">Joslin Diabetes Center and Beth Israel Medical Center, Harvard Medical School, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Joslin Diabetes Center and Beth Israel Medical Center, Harvard Medical School</wicri:cityArea></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation wicri:level="4"><nlm:aff id="A51">Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology (FA40), University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology (FA40), University Medical Center Groningen, PO Box 30001, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><affiliation wicri:level="1"><nlm:aff id="A52">Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, Amsterdam, The Netherlands, EMGO Institute Vumc, NESDA, AJ Ernststraat 1187, 1081 HL Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, Amsterdam, The Netherlands, EMGO Institute Vumc, NESDA, AJ Ernststraat 1187, 1081 HL Amsterdam</wicri:regionArea><wicri:noRegion>1081 HL Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation wicri:level="4"><nlm:aff id="A51">Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology (FA40), University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology (FA40), University Medical Center Groningen, PO Box 30001, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Del Greco, Fabiola" sort="Del Greco, Fabiola" uniqKey="Del Greco F" first="Fabiola" last="Del Greco">Fabiola Del Greco</name><affiliation wicri:level="1"><nlm:aff id="A53">Center for Biomedicine, European Academy of Bolzano (EURAC), Viale Druso, 1 - 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy of Bolzano (EURAC), Viale Druso, 1 - 39100 Bolzano</wicri:regionArea><wicri:noRegion>1 - 39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation wicri:level="3"><nlm:aff id="A54">Institute of Clinical Molecular Biology, Schittenhelmstr 12, 24105 Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Molecular Biology, Schittenhelmstr 12, 24105 Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Nothlings, Ute" sort="Nothlings, Ute" uniqKey="Nothlings U" first="Ute" last="Nöthlings">Ute Nöthlings</name><affiliation wicri:level="3"><nlm:aff id="A55">popgen Biobank, University Hospital Schleswig-Holstein, Niemannsweg 11, 24105 Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>popgen Biobank, University Hospital Schleswig-Holstein, Niemannsweg 11, 24105 Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A56">Section for Epidemiology, Institute for Experimental Medicine, Christian-Albrechts-University of Kiel, Niemannsweg 11, 24105 Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section for Epidemiology, Institute for Experimental Medicine, Christian-Albrechts-University of Kiel, Niemannsweg 11, 24105 Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Lieb, Wolfgang" sort="Lieb, Wolfgang" uniqKey="Lieb W" first="Wolfgang" last="Lieb">Wolfgang Lieb</name><affiliation wicri:level="3"><nlm:aff id="A57">Institute of Epidemiology and Biobank popgen, Christian-Albrechts University, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology and Biobank popgen, Christian-Albrechts University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Bakker, Stephan J L" sort="Bakker, Stephan J L" uniqKey="Bakker S" first="Stephan J. L." last="Bakker">Stephan J. L. Bakker</name><affiliation wicri:level="1"><nlm:aff id="A58">University Medical Center Groningen, University of Groningen, Dept. of Nephrology Groningen, The Netherlands, Dept Nephrology, UMC Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, University of Groningen, Dept. of Nephrology Groningen, The Netherlands, Dept Nephrology, UMC Groningen, PO Box 30001, 9700 RB Groningen</wicri:regionArea><wicri:noRegion>9700 RB Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Gansevoort, Ron T" sort="Gansevoort, Ron T" uniqKey="Gansevoort R" first="Ron T." last="Gansevoort">Ron T. Gansevoort</name><affiliation wicri:level="1"><nlm:aff id="A58">University Medical Center Groningen, University of Groningen, Dept. of Nephrology Groningen, The Netherlands, Dept Nephrology, UMC Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, University of Groningen, Dept. of Nephrology Groningen, The Netherlands, Dept Nephrology, UMC Groningen, PO Box 30001, 9700 RB Groningen</wicri:regionArea><wicri:noRegion>9700 RB Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation wicri:level="1"><nlm:aff id="A59">University Medical Center Groningen, University of Groningen, Dept. of Cardiology, Groningen, The Netherlands, Dept Cardiology, UMC Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, University of Groningen, Dept. of Cardiology, Groningen, The Netherlands, Dept Cardiology, UMC Groningen, PO Box 30001, 9700 RB Groningen</wicri:regionArea><wicri:noRegion>9700 RB Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation wicri:level="3"><nlm:aff id="A60">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><affiliation wicri:level="3"><nlm:aff id="A60">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="A60">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="3"><nlm:aff id="A60">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sedaghat, Sanaz" sort="Sedaghat, Sanaz" uniqKey="Sedaghat S" first="Sanaz" last="Sedaghat">Sanaz Sedaghat</name><affiliation wicri:level="3"><nlm:aff id="A60">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="3"><nlm:aff id="A60">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name><affiliation wicri:level="1"><nlm:aff id="A61">Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck, AUSTRIA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Autriche</country><wicri:regionArea>Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck</wicri:regionArea><wicri:noRegion>6020 Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name><affiliation wicri:level="1"><nlm:aff id="A61">Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck, AUSTRIA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Autriche</country><wicri:regionArea>Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck</wicri:regionArea><wicri:noRegion>6020 Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Kollerits, Barbara" sort="Kollerits, Barbara" uniqKey="Kollerits B" first="Barbara" last="Kollerits">Barbara Kollerits</name><affiliation wicri:level="1"><nlm:aff id="A61">Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck, AUSTRIA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Autriche</country><wicri:regionArea>Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck</wicri:regionArea><wicri:noRegion>6020 Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name><affiliation wicri:level="1"><nlm:aff id="A61">Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck, AUSTRIA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Autriche</country><wicri:regionArea>Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck</wicri:regionArea><wicri:noRegion>6020 Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name><affiliation><nlm:aff id="A62">First Department of Internal Medicine, Paracelsus Private Medical University Salzburg, Müllner Hauptstraße 48, 5020 Salzburg</nlm:aff><wicri:noCountry code="subfield">5020 Salzburg</wicri:noCountry></affiliation></author><author><name sortKey="Aumann, Nicole" sort="Aumann, Nicole" uniqKey="Aumann N" first="Nicole" last="Aumann">Nicole Aumann</name><affiliation wicri:level="1"><nlm:aff id="A63">Institute for Community Medicine, Walther-Rathenau-Str 48, 17487 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, Walther-Rathenau-Str 48, 17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name><affiliation wicri:level="1"><nlm:aff id="A64">Institute of Anatomy and Cell Biology, Friedrich-Loeffler-Str 23d, 17487 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Anatomy and Cell Biology, Friedrich-Loeffler-Str 23d, 17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Pietzner, Mike" sort="Pietzner, Mike" uniqKey="Pietzner M" first="Mike" last="Pietzner">Mike Pietzner</name><affiliation wicri:level="1"><nlm:aff id="A65">Institute for Clinical Chemistry and Laboratory Medicine, Ferdinant-Sauerbruch-Str, 17475 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Clinical Chemistry and Laboratory Medicine, Ferdinant-Sauerbruch-Str, 17475 Greifswald</wicri:regionArea><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation wicri:level="1"><nlm:aff id="A10">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Friedrich-Ludwig-Jahn-Str 15a, 17487 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Friedrich-Ludwig-Jahn-Str 15a, 17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name><affiliation wicri:level="1"><nlm:aff id="A66">Institute of Physiology University of Greifswald, Greifswalder Str 11c, 17495 Greifswald-Karlsburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Physiology University of Greifswald, Greifswalder Str 11c, 17495 Greifswald-Karlsburg</wicri:regionArea><wicri:noRegion>17495 Greifswald-Karlsburg</wicri:noRegion><wicri:noRegion>17495 Greifswald-Karlsburg</wicri:noRegion><wicri:noRegion>17495 Greifswald-Karlsburg</wicri:noRegion></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation wicri:level="1"><nlm:aff id="A67">Inserm, U744, Institut Pasteur de Lille, Université Lille-Nord de France, CHR&U de Lille, Service d'épidémiologie régional, CHRU Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U744, Institut Pasteur de Lille, Université Lille-Nord de France, CHR&U de Lille, Service d'épidémiologie régional, CHRU Lille</wicri:regionArea><wicri:noRegion>CHRU Lille</wicri:noRegion><wicri:noRegion>CHRU Lille</wicri:noRegion></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation wicri:level="1"><nlm:aff id="A68">Inserm, U897, Université Bordeaux 2, ISPED, ISPED, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U897, Université Bordeaux 2, ISPED, ISPED, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex</wicri:regionArea><wicri:noRegion>33076 Bordeaux cedex</wicri:noRegion><wicri:noRegion>33076 Bordeaux cedex</wicri:noRegion></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><nlm:aff id="A69">Inserm, U744, Institut Pasteur de Lille, Université Lille-Nord de France, INSTITUT PASTEUR, 1 RUE DU PROFESSEUR CALMETTE,BP 245,59019 LILLE, CX France</nlm:aff><wicri:noCountry code="subfield">CX France</wicri:noCountry></affiliation></author><author><name sortKey="Metzger, Marie" sort="Metzger, Marie" uniqKey="Metzger M" first="Marie" last="Metzger">Marie Metzger</name><affiliation wicri:level="1"><nlm:aff id="A70">Inserm, Univ Paris Sud, CESP, UMRS 1018, Team 10, Inserm U1018,CESP,Team 10, 16, avenue P Vaillant Couturier, 94 807 Villejuif cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Univ Paris Sud, CESP, UMRS 1018, Team 10, Inserm U1018,CESP,Team 10, 16, avenue P Vaillant Couturier, 94 807 Villejuif cedex</wicri:regionArea><wicri:noRegion>94 807 Villejuif cedex</wicri:noRegion><wicri:noRegion>94 807 Villejuif cedex</wicri:noRegion></affiliation></author><author><name sortKey="Stengel, Benedicte" sort="Stengel, Benedicte" uniqKey="Stengel B" first="Benedicte" last="Stengel">Benedicte Stengel</name><affiliation wicri:level="1"><nlm:aff id="A70">Inserm, Univ Paris Sud, CESP, UMRS 1018, Team 10, Inserm U1018,CESP,Team 10, 16, avenue P Vaillant Couturier, 94 807 Villejuif cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Univ Paris Sud, CESP, UMRS 1018, Team 10, Inserm U1018,CESP,Team 10, 16, avenue P Vaillant Couturier, 94 807 Villejuif cedex</wicri:regionArea><wicri:noRegion>94 807 Villejuif cedex</wicri:noRegion><wicri:noRegion>94 807 Villejuif cedex</wicri:noRegion></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland, Department of Clinical Chemistry, Fimlab Laboratories, Finn-Medi 2, 3th floor, PO Box 66, FI-33101 Tampere, FINLAND</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland, Department of Clinical Chemistry, Fimlab Laboratories, Finn-Medi 2, 3th floor, PO Box 66, FI-33101 Tampere</wicri:regionArea><wicri:noRegion>FI-33101 Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland, Department of Clinical Chemistry, Fimlab Laboratories, Finn-Medi 2, 3th floor, PO Box 66, FI-33101 Tampere, FINLAND</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland, Department of Clinical Chemistry, Fimlab Laboratories, Finn-Medi 2, 3th floor, PO Box 66, FI-33101 Tampere</wicri:regionArea><wicri:noRegion>FI-33101 Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:aff id="A72">Department of Clinical Physiology, Turku University Hospital, Turku 20521, Finland, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, POBox 52, 20521 Turku, FINLAND</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Clinical Physiology, Turku University Hospital, Turku 20521, Finland, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, POBox 52, 20521 Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Johnson, Andrew" sort="Johnson, Andrew" uniqKey="Johnson A" first="Andrew" last="Johnson">Andrew Johnson</name><affiliation wicri:level="1"><nlm:aff id="A73">NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702</wicri:regionArea><wicri:noRegion>Framingham MA 01702</wicri:noRegion></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation><nlm:aff id="A17">Department of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, University of Maryland School of Medicine, 660 W Redwood St, RM 492, Baltimore, MD, 21212</nlm:aff><wicri:noCountry code="subfield">21212</wicri:noCountry></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation wicri:level="1"><nlm:aff id="A74">Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 2, CH-1066 Epalinges, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 2, CH-1066 Epalinges</wicri:regionArea><wicri:noRegion>CH-1066 Epalinges</wicri:noRegion></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93042 Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93042 Regensburg</wicri:regionArea><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A46">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Goessling, Wolfram" sort="Goessling, Wolfram" uniqKey="Goessling W" first="Wolfram" last="Goessling">Wolfram Goessling</name><affiliation wicri:level="2"><nlm:aff id="A75">Divisions of Genetics and Gastroenterology, Department of Internal Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Divisions of Genetics and Gastroenterology, Department of Internal Medicine, Brigham and Women’s Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A76">Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Cambridge (Massachusetts)</settlement></placeName><orgName type="university">Université Harvard</orgName></affiliation></author><author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name><affiliation wicri:level="2"><nlm:aff id="A3">Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A77">Renal Division, Freiburg University Clinic, Germany, Berliner Allee 29, 79110 Freiburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Renal Division, Freiburg University Clinic, Germany, Berliner Allee 29, 79110 Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Kao, H Linda" sort="Kao, H Linda" uniqKey="Kao H" first="H. Linda" last="Kao">H. Linda Kao</name><affiliation wicri:level="2"><nlm:aff id="A3">Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A19">Welch Center for Prevention, Epidmiology and Clinical Research, 2024 E Monument St, Suite 2-600, Baltimore, MD 21287</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Welch Center for Prevention, Epidmiology and Clinical Research, 2024 E Monument St, Suite 2-600, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><affiliation wicri:level="1"><nlm:aff id="A6">NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702</wicri:regionArea><wicri:noRegion>Framingham MA 01702</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A78">Brigham and Women's Hospital Department of Endocrinology, 221 Longwood Ave, Boston MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital Department of Endocrinology, 221 Longwood Ave</wicri:cityArea></affiliation></author><author><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A." last="Böger">Carsten A. Böger</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Nephrology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93042 Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nephrology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93042 Regensburg</wicri:regionArea><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25493955</idno><idno type="pmc">4425568</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425568</idno><idno type="RBID">PMC:4425568</idno><idno type="doi">10.1038/ki.2014.361</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002D56</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002D56</idno><idno type="wicri:Area/Pmc/Curation">002C06</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C06</idno><idno type="wicri:Area/Pmc/Checkpoint">001561</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001561</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">002E16</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002E16</idno><idno type="wicri:Area/PubMed/Curation">002D40</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002D40</idno><idno type="wicri:Area/PubMed/Checkpoint">002D40</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002D40</idno><idno type="wicri:Area/Ncbi/Merge">002084</idno><idno type="wicri:Area/Ncbi/Curation">002084</idno><idno type="wicri:Area/Ncbi/Checkpoint">002084</idno><idno type="wicri:doubleKey">0085-2538:2014:Gorski M:genome:wide:association</idno><idno type="wicri:Area/Main/Merge">003943</idno><idno type="wicri:Area/Main/Curation">003907</idno><idno type="wicri:Area/Main/Exploration">003907</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genome-wide association study of kidney function decline in individuals of European descent</title><author><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93042 Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93042 Regensburg</wicri:regionArea><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Department of Nephrology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93042 Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nephrology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93042 Regensburg</wicri:regionArea><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name><affiliation wicri:level="2"><nlm:aff id="A3">Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Garnaas, Maija" sort="Garnaas, Maija" uniqKey="Garnaas M" first="Maija" last="Garnaas">Maija Garnaas</name><affiliation wicri:level="2"><nlm:aff id="A4">Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mcmahon, Gearoid M" sort="Mcmahon, Gearoid M" uniqKey="Mcmahon G" first="Gearoid M." last="Mcmahon">Gearoid M. Mcmahon</name><affiliation><nlm:aff id="A5">Brigham and Women's Hospital Division of Nephrology, 75 Francis St, Boston MA 02115</nlm:aff><wicri:noCountry code="subfield">Boston MA 02115</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702</wicri:regionArea><wicri:noRegion>Framingham MA 01702</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name><affiliation><nlm:aff id="A7">Brigham and Women's Hospital, Division of Preventive Medicine, 900 Commonwealth Ave, 3rd Floor, Boston MA 02215</nlm:aff><wicri:noCountry code="subfield">Boston MA 02215</wicri:noCountry></affiliation></author><author><name sortKey="Tayo, Bamidele O" sort="Tayo, Bamidele O" uniqKey="Tayo B" first="Bamidele O." last="Tayo">Bamidele O. Tayo</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Public Health Services, Loyola Medical Center, 2160 S First Avenue, Maywood, IL 60153, 2160 S First Avenue, Maywood, IL 60153</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Public Health Services, Loyola Medical Center, 2160 S First Avenue, Maywood, IL 60153, 2160 S First Avenue, Maywood</wicri:cityArea></affiliation></author><author><name sortKey="Pattaro, Cristian" sort="Pattaro, Cristian" uniqKey="Pattaro C" first="Cristian" last="Pattaro">Cristian Pattaro</name><affiliation><nlm:aff id="A9">Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Germany, Viale Druso, 1 - 39100 Bolzano (Italy)</nlm:aff><wicri:noCountry code="subfield">1 - 39100 Bolzano (Italy)</wicri:noCountry></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:aff id="A10">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Friedrich-Ludwig-Jahn-Str 15a, 17487 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Friedrich-Ludwig-Jahn-Str 15a, 17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name><affiliation wicri:level="2"><nlm:aff id="A7">Brigham and Women's Hospital, Division of Preventive Medicine, 900 Commonwealth Ave, 3rd Floor, Boston MA 02215</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital, Division of Preventive Medicine, 900 Commonwealth Ave, 3rd Floor</wicri:cityArea></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation wicri:level="4"><nlm:aff id="A11">The George Institute for Global Health, University of Sydney, PO Box M201 Missenden Rd, Sydney NSW 2050 Australia</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name><affiliation wicri:level="1"><nlm:aff id="A12">Centre de recherche du Centre hospitalier de l’Université de Montréal, University of Montreal, Canada, 2901 Rachel street East, Montreal (PQ) H1W 4A4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de recherche du Centre hospitalier de l’Université de Montréal, University of Montreal, Canada, 2901 Rachel street East, Montreal (PQ) H1W 4A4</wicri:regionArea><wicri:noRegion>Montreal (PQ) H1W 4A4</wicri:noRegion></affiliation></author><author><name sortKey="Tremblay, Johanne" sort="Tremblay, Johanne" uniqKey="Tremblay J" first="Johanne" last="Tremblay">Johanne Tremblay</name><affiliation><nlm:aff id="A13">CHUM Research Center- Technopôle Angus, 2901 Rachel Street office 301, Montreal (Québec) H1W4A4</nlm:aff><wicri:noCountry code="subfield">Montreal (Québec) H1W4A4</wicri:noCountry></affiliation></author><author><name sortKey="Woodward, Marc" sort="Woodward, Marc" uniqKey="Woodward M" first="Marc" last="Woodward">Marc Woodward</name><affiliation wicri:level="4"><nlm:aff id="A11">The George Institute for Global Health, University of Sydney, PO Box M201 Missenden Rd, Sydney NSW 2050 Australia</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name><affiliation wicri:level="1"><nlm:aff id="A14">Icelandic Heart Association, Research Institute, Holtasmari 1, 201 Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Research Institute, Holtasmari 1, 201 Kopavogur</wicri:regionArea><wicri:noRegion>201 Kopavogur</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">University of Iceland, Sæmundargötu 2, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Sæmundargötu 2, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name><affiliation wicri:level="1"><nlm:aff id="A14">Icelandic Heart Association, Research Institute, Holtasmari 1, 201 Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Research Institute, Holtasmari 1, 201 Kopavogur</wicri:regionArea><wicri:noRegion>201 Kopavogur</wicri:noRegion></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="A14">Icelandic Heart Association, Research Institute, Holtasmari 1, 201 Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Research Institute, Holtasmari 1, 201 Kopavogur</wicri:regionArea><wicri:noRegion>201 Kopavogur</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">University of Iceland, Sæmundargötu 2, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Sæmundargötu 2, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Harris, Tammara B" sort="Harris, Tammara B" uniqKey="Harris T" first="Tammara B." last="Harris">Tammara B. Harris</name><affiliation wicri:level="2"><nlm:aff id="A16">Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C-309, Bethesda MD 20892 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C-309</wicri:cityArea></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation wicri:level="2"><nlm:aff id="A16">Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C-309, Bethesda MD 20892 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, 3C-309</wicri:cityArea></affiliation></author><author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name><affiliation wicri:level="1"><nlm:aff id="A14">Icelandic Heart Association, Research Institute, Holtasmari 1, 201 Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Research Institute, Holtasmari 1, 201 Kopavogur</wicri:regionArea><wicri:noRegion>201 Kopavogur</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">University of Iceland, Sæmundargötu 2, 101 Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Sæmundargötu 2, 101 Reykjavik</wicri:regionArea><wicri:noRegion>101 Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation><nlm:aff id="A17">Department of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, University of Maryland School of Medicine, 660 W Redwood St, RM 492, Baltimore, MD, 21212</nlm:aff><wicri:noCountry code="subfield">21212</wicri:noCountry></affiliation><affiliation><nlm:aff id="A18">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, University of Maryland School of Medicine, 660 W Redwood St, RM 492, Baltimore, MD, 21212</nlm:aff><wicri:noCountry code="subfield">21212</wicri:noCountry></affiliation></author><author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name><affiliation><nlm:aff id="A17">Department of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, University of Maryland School of Medicine, 660 W Redwood St, RM 492, Baltimore, MD, 21212</nlm:aff><wicri:noCountry code="subfield">21212</wicri:noCountry></affiliation></author><author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><affiliation><nlm:aff id="A17">Department of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, University of Maryland School of Medicine, 660 W Redwood St, RM 492, Baltimore, MD, 21212</nlm:aff><wicri:noCountry code="subfield">21212</wicri:noCountry></affiliation><affiliation><nlm:aff id="A18">Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, University of Maryland School of Medicine, 660 W Redwood St, RM 492, Baltimore, MD, 21212</nlm:aff><wicri:noCountry code="subfield">21212</wicri:noCountry></affiliation></author><author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name><affiliation wicri:level="2"><nlm:aff id="A3">Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A19">Welch Center for Prevention, Epidmiology and Clinical Research, 2024 E Monument St, Suite 2-600, Baltimore, MD 21287</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Welch Center for Prevention, Epidmiology and Clinical Research, 2024 E Monument St, Suite 2-600, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name><affiliation wicri:level="2"><nlm:aff id="A3">Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Freudenberger, Paul" sort="Freudenberger, Paul" uniqKey="Freudenberger P" first="Paul" last="Freudenberger">Paul Freudenberger</name><affiliation wicri:level="1"><nlm:aff id="A20">Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria, Harrachgasse 21, 8010 Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria, Harrachgasse 21, 8010 Graz</wicri:regionArea><wicri:noRegion>8010 Graz</wicri:noRegion></affiliation></author><author><name sortKey="Hofer, Edith" sort="Hofer, Edith" uniqKey="Hofer E" first="Edith" last="Hofer">Edith Hofer</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology and Institute for Medical Informatics, Statistics and Documentation Medical University Graz, Austria, Auenbruggerplatz 22 and Auenbruggerplatz2, 8036 Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology and Institute for Medical Informatics, Statistics and Documentation Medical University Graz, Austria, Auenbruggerplatz 22 and Auenbruggerplatz2, 8036 Graz</wicri:regionArea><wicri:noRegion>8036 Graz</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A20">Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria, Harrachgasse 21, 8010 Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria, Harrachgasse 21, 8010 Graz</wicri:regionArea><wicri:noRegion>8010 Graz</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A22">Department of Neurology, Medical University Graz, Austria, Auenbruggerplatz 22, 8036 Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Graz, Austria, Auenbruggerplatz 22, 8036 Graz</wicri:regionArea><wicri:noRegion>8036 Graz</wicri:noRegion></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><nlm:aff id="A23">University of Newcastle, Centre for Clinical Epidemiology & Biostatistics, CReDITSS, HMRI, C/-University Drive, Callaghan NSW 2308, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Centre for Clinical Epidemiology & Biostatistics, CReDITSS, HMRI, C/-University Drive, Callaghan NSW 2308</wicri:regionArea><wicri:noRegion>Callaghan NSW 2308</wicri:noRegion></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation wicri:level="4"><nlm:aff id="A24">University of Sydney, Westmead Millennium Institute, Centre for Vision Research, Westmead Millennium Institute, University of Sydney C24, Westmead Hospital, NSW 2145 Australia</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation wicri:level="4"><nlm:aff id="A24">University of Sydney, Westmead Millennium Institute, Centre for Vision Research, Westmead Millennium Institute, University of Sydney C24, Westmead Hospital, NSW 2145 Australia</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="De Boer, Ian H" sort="De Boer, Ian H" uniqKey="De Boer I" first="Ian H." last="De Boer">Ian H. De Boer</name><affiliation wicri:level="2"><nlm:aff id="A25">University of Washington, Box 359606, 325 9th Ave, Seattle, WA 98104</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>University of Washington, Box 359606, 325 9th Ave, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name><affiliation wicri:level="4"><nlm:aff id="A26">Cardiovascular Health Research Unit, University of Washington, Seattle</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name><affiliation wicri:level="4"><nlm:aff id="A27">Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA (USA)</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name><affiliation wicri:level="3"><nlm:aff id="A28">Service of Medical Genetics, Lausanne University Hospital, DGM, rue du Bugnon 27, 1005,Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Service of Medical Genetics, Lausanne University Hospital, DGM, rue du Bugnon 27, 1005,Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A29">Swiss Institute of Bioinformatics, DGM, rue du Bugnon 27, 1005,Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Swiss Institute of Bioinformatics, DGM, rue du Bugnon 27, 1005,Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Corre, Tanguy" sort="Corre, Tanguy" uniqKey="Corre T" first="Tanguy" last="Corre">Tanguy Corre</name><affiliation wicri:level="3"><nlm:aff id="A28">Service of Medical Genetics, Lausanne University Hospital, DGM, rue du Bugnon 27, 1005,Lausanne, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Service of Medical Genetics, Lausanne University Hospital, DGM, rue du Bugnon 27, 1005,Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><affiliation><nlm:aff id="A30">Internal Medicine Department, Lausanne University Hospital, Rue du Bugnon 46, CH-1005 Lausanne</nlm:aff><wicri:noCountry code="subfield">CH-1005 Lausanne</wicri:noCountry></affiliation></author><author><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gérard" last="Waeber">Gérard Waeber</name><affiliation><nlm:aff id="A30">Internal Medicine Department, Lausanne University Hospital, Rue du Bugnon 46, CH-1005 Lausanne</nlm:aff><wicri:noCountry code="subfield">CH-1005 Lausanne</wicri:noCountry></affiliation></author><author><name sortKey="Gupta, Jayanta" sort="Gupta, Jayanta" uniqKey="Gupta J" first="Jayanta" last="Gupta">Jayanta Gupta</name><affiliation><nlm:aff id="A31">The Perelman School of Medicine at the University of Pennsylvania, Center for Clinical Epidemiology and Biostatistics</nlm:aff><wicri:noCountry code="subfield">Center for Clinical Epidemiology and Biostatistics</wicri:noCountry></affiliation></author><author><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name><affiliation><nlm:aff id="A31">The Perelman School of Medicine at the University of Pennsylvania, Center for Clinical Epidemiology and Biostatistics</nlm:aff><wicri:noCountry code="subfield">Center for Clinical Epidemiology and Biostatistics</wicri:noCountry></affiliation></author><author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name><affiliation wicri:level="1"><nlm:aff id="A6">NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702</wicri:regionArea><wicri:noRegion>Framingham MA 01702</wicri:noRegion></affiliation></author><author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93042 Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93042 Regensburg</wicri:regionArea><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702</wicri:regionArea><wicri:noRegion>Framingham MA 01702</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation wicri:level="1"><nlm:aff id="A6">NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702</wicri:regionArea><wicri:noRegion>Framingham MA 01702</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A32">Boston University School of Public Health, Department of Biostatistics, 715 Albany St, Boston, MA 02118</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University School of Public Health, Department of Biostatistics, 715 Albany St, Boston</wicri:cityArea></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation wicri:level="2"><nlm:aff id="A33">Mayo Clinic, 200 First Street SW, Rochester, MN 55905</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, 200 First Street SW, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name><affiliation wicri:level="2"><nlm:aff id="A33">Mayo Clinic, 200 First Street SW, Rochester, MN 55905</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, 200 First Street SW, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name><affiliation wicri:level="2"><nlm:aff id="A34">University of Michigan, 1415 Washington Heights, #4659, Ann Arbor, MI 48109-2019</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>University of Michigan, 1415 Washington Heights, #4659, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name><affiliation wicri:level="2"><nlm:aff id="A33">Mayo Clinic, 200 First Street SW, Rochester, MN 55905</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Mayo Clinic, 200 First Street SW, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Stafford, Jeanette M" sort="Stafford, Jeanette M" uniqKey="Stafford J" first="Jeanette M." last="Stafford">Jeanette M. Stafford</name><affiliation wicri:level="2"><nlm:aff id="A35">Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name><affiliation wicri:level="2"><nlm:aff id="A36">Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name><affiliation wicri:level="2"><nlm:aff id="A37">Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Barlassina, Cristina" sort="Barlassina, Cristina" uniqKey="Barlassina C" first="Cristina" last="Barlassina">Cristina Barlassina</name><affiliation wicri:level="1"><nlm:aff id="A38">Department of Health Science, University of Milano, Viale Ortles 22/4, 20139, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Science, University of Milano, Viale Ortles 22/4, 20139, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name><affiliation wicri:level="1"><nlm:aff id="A38">Department of Health Science, University of Milano, Viale Ortles 22/4, 20139, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Science, University of Milano, Viale Ortles 22/4, 20139, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation><affiliation><nlm:aff id="A39">Division of Nephrology, San Paolo Hospital, Via A Di Rudiní, 8 20142 MILANO</nlm:aff><wicri:noCountry code="subfield">8 20142 MILANO</wicri:noCountry></affiliation></author><author><name sortKey="Salvi, Erika" sort="Salvi, Erika" uniqKey="Salvi E" first="Erika" last="Salvi">Erika Salvi</name><affiliation wicri:level="1"><nlm:aff id="A38">Department of Health Science, University of Milano, Viale Ortles 22/4, 20139, Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Health Science, University of Milano, Viale Ortles 22/4, 20139, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A" last="Staessen">Jan A. Staessen</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Epidemiology, Maastricht University, Maastricht, Netherlands, PO Box 616, 6200 MD Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Maastricht University, Maastricht, Netherlands, PO Box 616, 6200 MD Maastricht</wicri:regionArea><wicri:noRegion>6200 MD Maastricht</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Sciences, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block d, Level 00, B-3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Sciences, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Block d, Level 00, B-3000 Leuven</wicri:regionArea><wicri:noRegion>B-3000 Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation wicri:level="2"><nlm:aff id="A7">Brigham and Women's Hospital, Division of Preventive Medicine, 900 Commonwealth Ave, 3rd Floor, Boston MA 02215</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital, Division of Preventive Medicine, 900 Commonwealth Ave, 3rd Floor</wicri:cityArea></affiliation></author><author><name sortKey="Grallert, Harald" sort="Grallert, Harald" uniqKey="Grallert H" first="Harald" last="Grallert">Harald Grallert</name><affiliation wicri:level="1"><nlm:aff id="A42">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A43">Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A44">German Center for Diabetes Research, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Diabetes Research, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name><affiliation wicri:level="1"><nlm:aff id="A42">Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation wicri:level="3"><nlm:aff id="A45">DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A46">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="A47">Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A48">Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K." last="Kr Mer">Bernhard K. Kr Mer</name><affiliation wicri:level="3"><nlm:aff id="A49">University Medical Centre Mannheim, 5th Department of Medicine, University of Heidelberg, Theodor Kutzer Ufer 1-3, 68167, Mannheim, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Medical Centre Mannheim, 5th Department of Medicine, University of Heidelberg, Theodor Kutzer Ufer 1-3, 68167, Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Kramer, Holly" sort="Kramer, Holly" uniqKey="Kramer H" first="Holly" last="Kramer">Holly Kramer</name><affiliation wicri:level="2"><nlm:aff id="A8">Department of Public Health Services, Loyola Medical Center, 2160 S First Avenue, Maywood, IL 60153, 2160 S First Avenue, Maywood, IL 60153</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Public Health Services, Loyola Medical Center, 2160 S First Avenue, Maywood, IL 60153, 2160 S First Avenue, Maywood</wicri:cityArea></affiliation></author><author><name sortKey="Rosas, Sylvia E" sort="Rosas, Sylvia E" uniqKey="Rosas S" first="Sylvia E." last="Rosas">Sylvia E. Rosas</name><affiliation wicri:level="2"><nlm:aff id="A50">Joslin Diabetes Center and Beth Israel Medical Center, Harvard Medical School, MA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Joslin Diabetes Center and Beth Israel Medical Center, Harvard Medical School</wicri:cityArea></affiliation></author><author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M." last="Nolte">Ilja M. Nolte</name><affiliation wicri:level="4"><nlm:aff id="A51">Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology (FA40), University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology (FA40), University Medical Center Groningen, PO Box 30001, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W." last="Penninx">Brenda W. Penninx</name><affiliation wicri:level="1"><nlm:aff id="A52">Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, Amsterdam, The Netherlands, EMGO Institute Vumc, NESDA, AJ Ernststraat 1187, 1081 HL Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, Amsterdam, The Netherlands, EMGO Institute Vumc, NESDA, AJ Ernststraat 1187, 1081 HL Amsterdam</wicri:regionArea><wicri:noRegion>1081 HL Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation wicri:level="4"><nlm:aff id="A51">Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology (FA40), University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology (FA40), University Medical Center Groningen, PO Box 30001, 9700 RB Groningen</wicri:regionArea><orgName type="university">Université de Groningue</orgName><placeName><settlement type="city">Groningue (ville)</settlement><region>Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Del Greco, Fabiola" sort="Del Greco, Fabiola" uniqKey="Del Greco F" first="Fabiola" last="Del Greco">Fabiola Del Greco</name><affiliation wicri:level="1"><nlm:aff id="A53">Center for Biomedicine, European Academy of Bolzano (EURAC), Viale Druso, 1 - 39100 Bolzano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Center for Biomedicine, European Academy of Bolzano (EURAC), Viale Druso, 1 - 39100 Bolzano</wicri:regionArea><wicri:noRegion>1 - 39100 Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name><affiliation wicri:level="3"><nlm:aff id="A54">Institute of Clinical Molecular Biology, Schittenhelmstr 12, 24105 Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Clinical Molecular Biology, Schittenhelmstr 12, 24105 Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Nothlings, Ute" sort="Nothlings, Ute" uniqKey="Nothlings U" first="Ute" last="Nöthlings">Ute Nöthlings</name><affiliation wicri:level="3"><nlm:aff id="A55">popgen Biobank, University Hospital Schleswig-Holstein, Niemannsweg 11, 24105 Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>popgen Biobank, University Hospital Schleswig-Holstein, Niemannsweg 11, 24105 Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A56">Section for Epidemiology, Institute for Experimental Medicine, Christian-Albrechts-University of Kiel, Niemannsweg 11, 24105 Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Section for Epidemiology, Institute for Experimental Medicine, Christian-Albrechts-University of Kiel, Niemannsweg 11, 24105 Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Lieb, Wolfgang" sort="Lieb, Wolfgang" uniqKey="Lieb W" first="Wolfgang" last="Lieb">Wolfgang Lieb</name><affiliation wicri:level="3"><nlm:aff id="A57">Institute of Epidemiology and Biobank popgen, Christian-Albrechts University, Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Epidemiology and Biobank popgen, Christian-Albrechts University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Bakker, Stephan J L" sort="Bakker, Stephan J L" uniqKey="Bakker S" first="Stephan J. L." last="Bakker">Stephan J. L. Bakker</name><affiliation wicri:level="1"><nlm:aff id="A58">University Medical Center Groningen, University of Groningen, Dept. of Nephrology Groningen, The Netherlands, Dept Nephrology, UMC Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, University of Groningen, Dept. of Nephrology Groningen, The Netherlands, Dept Nephrology, UMC Groningen, PO Box 30001, 9700 RB Groningen</wicri:regionArea><wicri:noRegion>9700 RB Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Gansevoort, Ron T" sort="Gansevoort, Ron T" uniqKey="Gansevoort R" first="Ron T." last="Gansevoort">Ron T. Gansevoort</name><affiliation wicri:level="1"><nlm:aff id="A58">University Medical Center Groningen, University of Groningen, Dept. of Nephrology Groningen, The Netherlands, Dept Nephrology, UMC Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, University of Groningen, Dept. of Nephrology Groningen, The Netherlands, Dept Nephrology, UMC Groningen, PO Box 30001, 9700 RB Groningen</wicri:regionArea><wicri:noRegion>9700 RB Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation wicri:level="1"><nlm:aff id="A59">University Medical Center Groningen, University of Groningen, Dept. of Cardiology, Groningen, The Netherlands, Dept Cardiology, UMC Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Groningen, University of Groningen, Dept. of Cardiology, Groningen, The Netherlands, Dept Cardiology, UMC Groningen, PO Box 30001, 9700 RB Groningen</wicri:regionArea><wicri:noRegion>9700 RB Groningen</wicri:noRegion></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation wicri:level="3"><nlm:aff id="A60">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name><affiliation wicri:level="3"><nlm:aff id="A60">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><nlm:aff id="A60">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation wicri:level="3"><nlm:aff id="A60">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sedaghat, Sanaz" sort="Sedaghat, Sanaz" uniqKey="Sedaghat S" first="Sanaz" last="Sedaghat">Sanaz Sedaghat</name><affiliation wicri:level="3"><nlm:aff id="A60">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G." last="Uitterlinden">André G. Uitterlinden</name><affiliation wicri:level="3"><nlm:aff id="A60">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name><affiliation wicri:level="1"><nlm:aff id="A61">Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck, AUSTRIA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Autriche</country><wicri:regionArea>Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck</wicri:regionArea><wicri:noRegion>6020 Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name><affiliation wicri:level="1"><nlm:aff id="A61">Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck, AUSTRIA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Autriche</country><wicri:regionArea>Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck</wicri:regionArea><wicri:noRegion>6020 Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Kollerits, Barbara" sort="Kollerits, Barbara" uniqKey="Kollerits B" first="Barbara" last="Kollerits">Barbara Kollerits</name><affiliation wicri:level="1"><nlm:aff id="A61">Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck, AUSTRIA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Autriche</country><wicri:regionArea>Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck</wicri:regionArea><wicri:noRegion>6020 Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name><affiliation wicri:level="1"><nlm:aff id="A61">Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck, AUSTRIA</nlm:aff><country xml:lang="fr" wicri:curation="lc">Autriche</country><wicri:regionArea>Innsbruck Medical University, Division of Genetic Epidemiology, Schöpfstraße 41, 6020 Innsbruck</wicri:regionArea><wicri:noRegion>6020 Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name><affiliation><nlm:aff id="A62">First Department of Internal Medicine, Paracelsus Private Medical University Salzburg, Müllner Hauptstraße 48, 5020 Salzburg</nlm:aff><wicri:noCountry code="subfield">5020 Salzburg</wicri:noCountry></affiliation></author><author><name sortKey="Aumann, Nicole" sort="Aumann, Nicole" uniqKey="Aumann N" first="Nicole" last="Aumann">Nicole Aumann</name><affiliation wicri:level="1"><nlm:aff id="A63">Institute for Community Medicine, Walther-Rathenau-Str 48, 17487 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Community Medicine, Walther-Rathenau-Str 48, 17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name><affiliation wicri:level="1"><nlm:aff id="A64">Institute of Anatomy and Cell Biology, Friedrich-Loeffler-Str 23d, 17487 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Anatomy and Cell Biology, Friedrich-Loeffler-Str 23d, 17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Pietzner, Mike" sort="Pietzner, Mike" uniqKey="Pietzner M" first="Mike" last="Pietzner">Mike Pietzner</name><affiliation wicri:level="1"><nlm:aff id="A65">Institute for Clinical Chemistry and Laboratory Medicine, Ferdinant-Sauerbruch-Str, 17475 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Clinical Chemistry and Laboratory Medicine, Ferdinant-Sauerbruch-Str, 17475 Greifswald</wicri:regionArea><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion><wicri:noRegion>17475 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation wicri:level="1"><nlm:aff id="A10">Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Friedrich-Ludwig-Jahn-Str 15a, 17487 Greifswald, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Friedrich-Ludwig-Jahn-Str 15a, 17487 Greifswald</wicri:regionArea><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion><wicri:noRegion>17487 Greifswald</wicri:noRegion></affiliation></author><author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name><affiliation wicri:level="1"><nlm:aff id="A66">Institute of Physiology University of Greifswald, Greifswalder Str 11c, 17495 Greifswald-Karlsburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Physiology University of Greifswald, Greifswalder Str 11c, 17495 Greifswald-Karlsburg</wicri:regionArea><wicri:noRegion>17495 Greifswald-Karlsburg</wicri:noRegion><wicri:noRegion>17495 Greifswald-Karlsburg</wicri:noRegion><wicri:noRegion>17495 Greifswald-Karlsburg</wicri:noRegion></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation wicri:level="1"><nlm:aff id="A67">Inserm, U744, Institut Pasteur de Lille, Université Lille-Nord de France, CHR&U de Lille, Service d'épidémiologie régional, CHRU Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U744, Institut Pasteur de Lille, Université Lille-Nord de France, CHR&U de Lille, Service d'épidémiologie régional, CHRU Lille</wicri:regionArea><wicri:noRegion>CHRU Lille</wicri:noRegion><wicri:noRegion>CHRU Lille</wicri:noRegion></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation wicri:level="1"><nlm:aff id="A68">Inserm, U897, Université Bordeaux 2, ISPED, ISPED, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U897, Université Bordeaux 2, ISPED, ISPED, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex</wicri:regionArea><wicri:noRegion>33076 Bordeaux cedex</wicri:noRegion><wicri:noRegion>33076 Bordeaux cedex</wicri:noRegion></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation><nlm:aff id="A69">Inserm, U744, Institut Pasteur de Lille, Université Lille-Nord de France, INSTITUT PASTEUR, 1 RUE DU PROFESSEUR CALMETTE,BP 245,59019 LILLE, CX France</nlm:aff><wicri:noCountry code="subfield">CX France</wicri:noCountry></affiliation></author><author><name sortKey="Metzger, Marie" sort="Metzger, Marie" uniqKey="Metzger M" first="Marie" last="Metzger">Marie Metzger</name><affiliation wicri:level="1"><nlm:aff id="A70">Inserm, Univ Paris Sud, CESP, UMRS 1018, Team 10, Inserm U1018,CESP,Team 10, 16, avenue P Vaillant Couturier, 94 807 Villejuif cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Univ Paris Sud, CESP, UMRS 1018, Team 10, Inserm U1018,CESP,Team 10, 16, avenue P Vaillant Couturier, 94 807 Villejuif cedex</wicri:regionArea><wicri:noRegion>94 807 Villejuif cedex</wicri:noRegion><wicri:noRegion>94 807 Villejuif cedex</wicri:noRegion></affiliation></author><author><name sortKey="Stengel, Benedicte" sort="Stengel, Benedicte" uniqKey="Stengel B" first="Benedicte" last="Stengel">Benedicte Stengel</name><affiliation wicri:level="1"><nlm:aff id="A70">Inserm, Univ Paris Sud, CESP, UMRS 1018, Team 10, Inserm U1018,CESP,Team 10, 16, avenue P Vaillant Couturier, 94 807 Villejuif cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, Univ Paris Sud, CESP, UMRS 1018, Team 10, Inserm U1018,CESP,Team 10, 16, avenue P Vaillant Couturier, 94 807 Villejuif cedex</wicri:regionArea><wicri:noRegion>94 807 Villejuif cedex</wicri:noRegion><wicri:noRegion>94 807 Villejuif cedex</wicri:noRegion></affiliation></author><author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland, Department of Clinical Chemistry, Fimlab Laboratories, Finn-Medi 2, 3th floor, PO Box 66, FI-33101 Tampere, FINLAND</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland, Department of Clinical Chemistry, Fimlab Laboratories, Finn-Medi 2, 3th floor, PO Box 66, FI-33101 Tampere</wicri:regionArea><wicri:noRegion>FI-33101 Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><affiliation wicri:level="1"><nlm:aff id="A71">Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland, Department of Clinical Chemistry, Fimlab Laboratories, Finn-Medi 2, 3th floor, PO Box 66, FI-33101 Tampere, FINLAND</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland, Department of Clinical Chemistry, Fimlab Laboratories, Finn-Medi 2, 3th floor, PO Box 66, FI-33101 Tampere</wicri:regionArea><wicri:noRegion>FI-33101 Tampere</wicri:noRegion></affiliation></author><author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name><affiliation wicri:level="1"><nlm:aff id="A72">Department of Clinical Physiology, Turku University Hospital, Turku 20521, Finland, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, POBox 52, 20521 Turku, FINLAND</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Department of Clinical Physiology, Turku University Hospital, Turku 20521, Finland, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, POBox 52, 20521 Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author><author><name sortKey="Johnson, Andrew" sort="Johnson, Andrew" uniqKey="Johnson A" first="Andrew" last="Johnson">Andrew Johnson</name><affiliation wicri:level="1"><nlm:aff id="A73">NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702</wicri:regionArea><wicri:noRegion>Framingham MA 01702</wicri:noRegion></affiliation></author><author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><affiliation><nlm:aff id="A17">Department of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, University of Maryland School of Medicine, 660 W Redwood St, RM 492, Baltimore, MD, 21212</nlm:aff><wicri:noCountry code="subfield">21212</wicri:noCountry></affiliation></author><author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name><affiliation wicri:level="1"><nlm:aff id="A74">Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 2, CH-1066 Epalinges, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 2, CH-1066 Epalinges</wicri:regionArea><wicri:noRegion>CH-1066 Epalinges</wicri:noRegion></affiliation></author><author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93042 Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93042 Regensburg</wicri:regionArea><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A46">Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg</wicri:regionArea><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion><wicri:noRegion>Neuherberg</wicri:noRegion></affiliation></author><author><name sortKey="Goessling, Wolfram" sort="Goessling, Wolfram" uniqKey="Goessling W" first="Wolfram" last="Goessling">Wolfram Goessling</name><affiliation wicri:level="2"><nlm:aff id="A75">Divisions of Genetics and Gastroenterology, Department of Internal Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Divisions of Genetics and Gastroenterology, Department of Internal Medicine, Brigham and Women’s Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A76">Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Cambridge (Massachusetts)</settlement></placeName><orgName type="university">Université Harvard</orgName></affiliation></author><author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name><affiliation wicri:level="2"><nlm:aff id="A3">Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A77">Renal Division, Freiburg University Clinic, Germany, Berliner Allee 29, 79110 Freiburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Renal Division, Freiburg University Clinic, Germany, Berliner Allee 29, 79110 Freiburg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Kao, H Linda" sort="Kao, H Linda" uniqKey="Kao H" first="H. Linda" last="Kao">H. Linda Kao</name><affiliation wicri:level="2"><nlm:aff id="A3">Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dept. of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A19">Welch Center for Prevention, Epidmiology and Clinical Research, 2024 E Monument St, Suite 2-600, Baltimore, MD 21287</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Welch Center for Prevention, Epidmiology and Clinical Research, 2024 E Monument St, Suite 2-600, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name><affiliation wicri:level="1"><nlm:aff id="A6">NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI's Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham MA 01702</wicri:regionArea><wicri:noRegion>Framingham MA 01702</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="A78">Brigham and Women's Hospital Department of Endocrinology, 221 Longwood Ave, Boston MA 02115</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Brigham and Women's Hospital Department of Endocrinology, 221 Longwood Ave</wicri:cityArea></affiliation></author><author><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A." last="Böger">Carsten A. Böger</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Nephrology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93042 Regensburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Nephrology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93042 Regensburg</wicri:regionArea><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion><wicri:noRegion>93042 Regensburg</wicri:noRegion></affiliation></author></analytic><series><title level="j">Kidney international</title><idno type="ISSN">0085-2538</idno><idno type="eISSN">1523-1755</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cadherins (genetics)</term><term>European Continental Ancestry Group (genetics)</term><term>Genome, Human</term><term>Genome-Wide Association Study</term><term>Glomerular Filtration Rate (genetics)</term><term>Humans</term><term>N-Acetylgalactosaminyltransferases (genetics)</term><term>Renal Insufficiency (genetics)</term><term>Uromodulin (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cadhérines (génétique)</term><term>Génome humain</term><term>Humains</term><term>Insuffisance rénale (génétique)</term><term>N-acetylgalactosaminyltransferase (génétique)</term><term>Population d'origine européenne (génétique)</term><term>Taux de filtration glomérulaire (génétique)</term><term>Uromoduline (génétique)</term><term>Étude d'association pangénomique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cadherins</term><term>N-Acetylgalactosaminyltransferases</term><term>Uromodulin</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>European Continental Ancestry Group</term><term>Glomerular Filtration Rate</term><term>Renal Insufficiency</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cadhérines</term><term>Insuffisance rénale</term><term>N-acetylgalactosaminyltransferase</term><term>Population d'origine européenne</term><term>Taux de filtration glomérulaire</term><term>Uromoduline</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Genome, Human</term><term>Genome-Wide Association Study</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Génome humain</term><term>Humains</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">Genome wide association studies (GWAS) have identified multiple loci associated with cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time is missing. Here we conducted a GWAS meta-analysis among 63,558 participants of European descent, initially from 16 cohorts with serial kidney function measurements within the CKDGen Consortium, followed by independent replication among additional participants from 13 cohorts. In stage 1 GWAS meta-analysis, SNPs at <italic>MEOX2, GALNT11, IL1RAP, NPPA, HPCAL1</italic> and <italic>CDH23</italic> showed the strongest associations for at least one trait, in addition to the known <italic>UMOD</italic> locus which showed genome-wide significance with an annual change in eGFR. In stage 2 meta-analysis, the significant association at <italic>UMOD</italic> was replicated. Associations at <italic>GALNT11</italic> with Rapid Decline (annual eGFRdecline of 3ml/min/1.73m<sup>2</sup> or more), and <italic>CDH23</italic> with eGFR change among those with CKD showed significant suggestive evidence of replication. Combined stage 1 and 2 meta-analyses showed significance for <italic>UMOD, GALNT11</italic> and <italic>CDH23</italic>. Morpholino knockdowns of <italic>galnt11</italic> and <italic>cdh23</italic> in zebrafish embryos each had signs of severe edema 72 hours after gentamicin treatment compared to controls, but no gross morphological renal abnormalities before gentamicin administration. Thus, our results suggest a role in the deterioration of kidney function for the loci <italic>GALNT11</italic> and <italic>CDH23</italic>, and show that the <italic>UMOD</italic> locus is significantly associated with kidney function decline.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Coresh, J" uniqKey="Coresh J">J Coresh</name></author><author><name sortKey="Selvin, E" uniqKey="Selvin E">E Selvin</name></author><author><name sortKey="Stevens, La" uniqKey="Stevens L">LA Stevens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meguid El Nahas, A" uniqKey="Meguid El Nahas A">A Meguid El Nahas</name></author><author><name sortKey="Bello, Ak" uniqKey="Bello A">AK Bello</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Matsushita, K" uniqKey="Matsushita K">K Matsushita</name></author><author><name sortKey="Selvin, E" uniqKey="Selvin E">E 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Coresh</name></author><author><name sortKey="Astor, Bc" uniqKey="Astor B">BC Astor</name></author><author><name sortKey="Mcquillan, G" uniqKey="Mcquillan G">G McQuillan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Almasy, L" uniqKey="Almasy L">L Almasy</name></author><author><name sortKey="Blangero, J" uniqKey="Blangero J">J Blangero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thorisson, Ga" uniqKey="Thorisson G">GA Thorisson</name></author><author><name sortKey="Smith, Av" uniqKey="Smith A">AV Smith</name></author><author><name sortKey="Krishnan, L" uniqKey="Krishnan L">L Krishnan</name></author><author><name sortKey="Stein, Ld" uniqKey="Stein L">LD Stein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuchsberger, C" uniqKey="Fuchsberger C">C Fuchsberger</name></author><author><name sortKey="Taliun, D" uniqKey="Taliun D">D Taliun</name></author><author><name 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Ia" uniqKey="Drummond I">IA Drummond</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Canada</li><li>Finlande</li><li>France</li><li>Islande</li><li>Italie</li><li>Pays-Bas</li><li>Suisse</li><li>États-Unis</li></country><region><li>Bade-Wurtemberg</li><li>Bavière</li><li>Canton de Vaud</li><li>Caroline du Nord</li><li>District de Fribourg-en-Brisgau</li><li>District de Haute-Bavière</li><li>District de Karlsruhe</li><li>Finlande occidentale</li><li>Groningue (province)</li><li>Hollande-Méridionale</li><li>Illinois</li><li>Maryland</li><li>Massachusetts</li><li>Michigan</li><li>Minnesota</li><li>Nouvelle-Galles du Sud</li><li>Schleswig-Holstein</li><li>Washington (État)</li></region><settlement><li>Cambridge (Massachusetts)</li><li>Fribourg-en-Brisgau</li><li>Groningue (ville)</li><li>Kiel</li><li>Lausanne</li><li>Mannheim</li><li>Munich</li><li>Rotterdam</li><li>Seattle</li><li>Sydney</li><li>Turku</li></settlement><orgName><li>Université Harvard</li><li>Université de Groningue</li><li>Université de Sydney</li><li>Université de Washington</li></orgName></list><tree><noCountry><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name><name sortKey="Gupta, Jayanta" sort="Gupta, Jayanta" uniqKey="Gupta J" first="Jayanta" last="Gupta">Jayanta Gupta</name><name sortKey="Kanetsky, Peter A" sort="Kanetsky, Peter A" uniqKey="Kanetsky P" first="Peter A." last="Kanetsky">Peter A. Kanetsky</name><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name><name sortKey="Pattaro, Cristian" sort="Pattaro, Cristian" uniqKey="Pattaro C" first="Cristian" last="Pattaro">Cristian Pattaro</name><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name><name sortKey="Tremblay, Johanne" sort="Tremblay, Johanne" uniqKey="Tremblay J" first="Johanne" last="Tremblay">Johanne Tremblay</name><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name><name sortKey="Waeber, Gerard" sort="Waeber, Gerard" uniqKey="Waeber G" first="Gérard" last="Waeber">Gérard Waeber</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name></noRegion><name sortKey="Aumann, Nicole" sort="Aumann, Nicole" uniqKey="Aumann N" first="Nicole" last="Aumann">Nicole Aumann</name><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A." last="Böger">Carsten A. 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Staessen</name></noRegion></country><country name="France"><noRegion><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name></noRegion><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><name sortKey="Metzger, Marie" sort="Metzger, Marie" uniqKey="Metzger M" first="Marie" last="Metzger">Marie Metzger</name><name sortKey="Stengel, Benedicte" sort="Stengel, Benedicte" uniqKey="Stengel B" first="Benedicte" last="Stengel">Benedicte Stengel</name></country><country name="Finlande"><noRegion><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name></noRegion><name sortKey="Lyytik Inen, Leo Pekka" sort="Lyytik Inen, Leo Pekka" uniqKey="Lyytik Inen L" first="Leo-Pekka" last="Lyytik Inen">Leo-Pekka Lyytik Inen</name><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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